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Figure 6 | Fluids and Barriers of the CNS

Figure 6

From: Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP

Figure 6

Degenerative changes in hydrocephalic rat vessels compared to controls (arrows). (A) Age-matched sham-operated control demonstrating a normal appearing parenchymal vessel. (B) six-month-old tgAPP21 rat at 10 weeks post-kaolin showing very subtle vascular changes. (C) six-month-old tgAPP21 rat six months post hydrocephalus induction demonstrating rather marked vessel wall degenerative changes and expansion of the Virchow-Robin space. Verhoeff-Van Gieson stain, ×200.

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Fluids and Barriers of the CNS

ISSN: 2045-8118