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Figure 5 | Fluids and Barriers of the CNS

Figure 5

From: Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP

Figure 5

Oligomeric Aβ in tgAPP21hydrocephalic rat frontoparietal cortex compared to control rat (arrows). Top row: six-month-old rat. (A) sham-operated control brain showing minimal immunostaining for oligomeric forms, ×200. (B) six-month-old rat 10 weeks post-kaolin hydrocephalus, ×200. There is a marked increase in immunoreactive product. Bottom row: 12-month-old rat. (C) sham-operated control showing moderate immunoreactivity for oligomeric Aβ, ×200. (D) 12-month-old rat 10 weeks post-kaolin hydrocephalus showing a significant increase in oligomeric Aβ, ×200.

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Fluids and Barriers of the CNS

ISSN: 2045-8118