Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus

Table 1 Patient characteristics

	DESH	non-DESH	p value
Gender (male/female)	4/6	6/6
Age (years)	75.7 ± 4.4	77 ± 9.3	0.17
Tap positive	8	5
Shunt operation	7	3
Shunt success	6	2
AChE inhibitor prescription	3	5
Opening CSF pressure (cmH₂O)	14.8 ± 1.7	14.8 ± 1.3	0.99
Evans index (%)	34.5 ± 2.8	32.7 ± 4.3	0.27
Callosal angle (degrees)	79.9 ± 5.5	101.2 ± 4.3	0.01*
ARWMC	9.2 ± 1.6	13.3 ± 2.0	0.19
MMSE	22.5 ± 4.6	18.1 ± 6.4	0.05
FAB	11.4 ± 4.0	9.9 ± 4.0	0.27
TUG (s)	17.8 ± 0.8	29.8 ± 5.7	0.04*
TUG (step)	24.2 ± 0.6	38 ± 5.0	0.01*
iNPHGS	7.3 ± 0.9	9.1 ± 1.0	0.24
t-tau (pg/mL)	319.9 ± 31	546.2 ± 54	0.003*
Aβ42 (pM)	59.2 ± 7.5	57.2 ± 6.0	0.84
Aβ40 (pM)	1198 ± 76	1314 ± 45	0.19
L-PGDS (μg/mL)	14.4 ± 1.0	20.8 ± 2.0	0.01*

Data are numbers or the mean ± the standard deviation. iNPH: idiopathic normal pressure hydrocephalus, DESH, disproportionately enlarged subarachnoid-space hydrocephalus, AChE: acetylcholinesterase, ARWMC: age related white matter change, MMSE: mini-mental state examination, FAB: frontal assessment battery, TUG: timed up and go test, iNPHGS: iNPH grading scale, t-tau: total tau, Aβ: amyloid beta, L-PGDS: lipocalin-type prostaglandin D synthase. *: p < 0.05.

ISSN: 2045-8118