Figure 2
From: Neural stem cells: are they the hope of a better life for patients with fetal-onset hydrocephalus?
Clinical outcome is related to the disruption of the ventricular zone. The disruption of the ventricular zone (VZ) through effects on cell junction proteins can result from a variety of causes including abnormal trafficking of proteins to membrane, bleeding/hemorrhage and viral infections. The disruption of the ventricular zone in the telencephalon leads to abnormal neurogenesis. The disruption of the ventricular zone in the Sylvian aqueduct leads to aqueduct obstruction and hydrocephalus. Hydrocephalus may also result from loss of cerebral tissue (cerebral atrophy) and excessive production of cerebrospinal fluid (CSF).