Figure 3
CSF outflow correlated with drug concentration at (A) 25 cmH 2 O and (B) 45 cmH 2 O ICP. In order to address whether a correlation existed between CSF outflow and an overall drug effect, data points from all agents tested at no drug treatment (NT), the delivery of the first set of agents (Drug Conc.#1; 50 μM NA, 10 μM L-NMMA, 0.1 μM U46619) and the delivery of the second set of agents (Drug Conc.#2; 500 μM NA, 100 μM L-NMMA, 1 μM U46619) were plotted against CSF outflow, which was calculated from linear regression analysis derived from the raw data using steady-state pressures of (A) 25 cmH2O and (B) by extrapolation at 45 cmH2O. The straight line linking the averages within each treatment group was calculated with the Pearson correlation test.