From: Oral antioxidant therapy for juvenile rats with kaolin-induced hydrocephalus
 | Nonhydrocephalic controls | Vehicle (30% canola) | Dextrose | Low dose antiox.†| High dose antiox.†|
---|---|---|---|---|---|
Sample size | 8 | 11 | 10 | 11 | 10 |
Ventricle area index (pre-treat) | 0.006 ± 0.0007 | 0.114 ± 0.013** | 0.119 ± 0.016** | 0.107 ± 0.015** | 0.118 ± 0.015** |
Ventricle area index (post-treat) | 0.012 ± 0.003 | 0.140 ± 0.018**# | 0.169 ± 0.027**# | 0.125 ± 0.013**# | 0.140 ± 0.010**# |
Percent enlargement ventricles during treatment | - | 22.5 ± 8.1 | 40.1 ± 6.2 | 23.0 ± 6.8 | 25.1 ± 8.3 |
Body weight (g) (pre-treat) | 169.3 ± 4.6 | 123.3 ± 7.2** | 135.2 ± 8.2** | 116.9 ± 6.4** | 112.7 ± 5.3** |
Body weight (g) (post-treat) | 269.3 ± 6.7# | 200.2 ± 13.4**# | 219.4 ± 13.5*# | 175.4 ± 12.5**# | 179.6 ± 12.0**# |
Rearing activity (post-treat) (beam breaks - 5 min) | 100 ± 12 | 67 ± 12 | 96 ± 8 | 78 ± 16 | 82 ± 16 |
Ambulatory activity (post-treat) (beam breaks - 5 min) | 466 ± 35 | 334 ± 31*# | 548 ± 54# | 461 ± 39# | 396 ± 53# |
Total activity (post-treat) (beam breaks - 5 min) | 618 ± 41 | 459 ± 38*# | 713 ± 54# | 637 ± 41# | 558 ± 53# |
Endurance of rotarod (cont. speed, post-treat) (sec) | 33 ± 8 | 32 ± 10 | 37 ± 7 | 66 ± 15# | 38 ± 11 |
Endurance of rotarod (accelerating speed, post-treat) (sec) | 57 ± 15 | 56 ± 11# | 73 ± 14# | 65 ± 13# | 71 ± 13# |
Morris water maze test (post-treat, 3 trials mean) (sec) | 7.67 ± 0.85# | 6.98 ± 1.10# | 5.89 ± 0.61# | 5.15 ± 0.41*# | 4.46 ± 0.46**# |
Swim time 150 cm (post-treat) (sec) | 24.3 ± 6.7 | 13.4 ± 2.0 | 20.9 ± 3.4 | 18.0 ± 3.4# | 17.0 ± 3.1 |
Lateral corpus callosum thickness (μm) | 315 ± 16 | 208 ± 14** | 220 ± 20** | 220 ± 18** | 208 ± 13** |
GFAP content (ELISA) frontal cerebrum (mg GFAP/g protein) | 0.68 ± 0.16 | 1.08 ± 0.19 | 1.29 ± 0.24 | 1.11 ± 0.16 | 1.10 ± 0.25 |
MBP content (ELISA) frontal cerebrum (mg MBP/g protein) | 2.30 ± 0.26 | 2.42 ± 0.28 | 2.91 ± 0.28 | 2.70 ± 0.35 | 2.30 ± 0.16 |
MDA level (TBARS) parietal cerebrum (μM MDA/g wet tissue) | 111.98 ± 10.57 | 145.32 ± 8.94* | 138.99 ± 9.41 | 146.89 ± 9.67* | 141.35 ± 8.45* |
ABTS + content (antioxidant capacity) hippocampus (mM) | 0.580 ± 0.029 | 0.582 ± 0.025 | 0.467 ± 0.062 | 0.589 ± 0.019 | 0.574 ± 0.026 |