Table 1 Results of antioxidant treatment on hydrocephalic rats (Trial 1)*
From: Oral antioxidant therapy for juvenile rats with kaolin-induced hydrocephalus
|  | Dextrose | Low dose antiox.†| High dose antiox.†|
|---|---|---|---|
Sample size | 14 | 14 | 15 |
Ventricle area index (pre-treat) | 0.130 ± 0.010 | 0.128 ± 0.008 | 0.145 ± 0.021 |
Ventricle area index (post-treat) | 0.141 ± 0.012# | 0.138 ± 0.009# | 0.198 ± 0.039# |
Percent enlargement ventricles during treatment | 9.3 ± 3.1 | 8.6 ± 2.0 | 33.5 ± 18.7 |
Body weight (g) (pre-treat) | 106.1 ± 2.4 | 103.7 ± 1.1 | 106.6 ± 3.3 |
Body weight (g) (post-treat) | 223.8 ± 4.5 | 223.1 ± 3.2 | 222.8 ± 7.0 |
Rearing activity (post-treat) (beam breaks in 5 min) | 108 ± 18 | 146 ± 18 | 166 ± 26 |
Ambulatory activity (post-treat) (beam breaks in 5 min) | 760 ± 85 | 824 ± 87 | 1284 ± 221 |
Total activity (post-treat) (beam breaks in 5 min) | 1089 ± 107 | 1210 ± 107 | 1684 ± 248 |
Endurance of rotarod (cont. speed, post-treat) (sec) | 60 ± 12 | 64 ± 11 | 44 ± 11 |
Endurance of rotarod (accelerating speed, post-treat) (sec) | 21 ± 6 | 27 ± 6 | 25 ± 8 |
Morris water maze test (post-treat, 3 trials mean) (sec) | 15.98 ± 1.21 | 15.17 ± 1.82 | 33.86 ± 12.17 |
Swim time 150 cm (post-treat) (sec) | 11.98 ± 1.31 | 16.45 ± 1.87 | 14.31 ± 1.78 |
GFAP content (ELISA) frontal cerebrum (mg GFAP/g protein) | 1.30 ± 0.13 | 1.54 ± 0.31 | 1.56 ± 0.32 |
MBP content (ELISA) frontal cerebrum (mg MBP/g protein) | 5.19 ± 0.19 | 5.31 ± 0.12 | 5.24 ± 0.25 |