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Figure 1 | Fluids and Barriers of the CNS

Figure 1

From: Extravasation into brain and subsequent spread beyond the ischemic core of a magnetic resonance contrast agent following a step-down infusion protocol in acute cerebral ischemia

Figure 1

Images to exemplify the areas of ADC and CBF deficits (demarcated by white outlines) during occlusion (top row), and after reperfusion (middle row). Images were acquired 1.5-2.5 h post-stroke and 0.5-3.0 h post re-perfusion. Note the expansion of ADC lesion by a small extent and the partial restitution of CBF after reperfusion indicated by the appearance of relatively brighter pixels in the CBF deficit region. The animals were sacrificed following the MRCA enhanced imaging series (performed between 2.5 h and 3.0 h post-reperfusion) at approximately 3 h post-reperfusion and tissue sections were taken for histopathological assessment. The bottom photomicrograph shows the Nissl stained brain section from the same animal and demonstrates the stroke lesion (white outline) as seen on histopathology. It approximates the area of CBF deficit still persisting after reperfusion. An increase in Nissl staining intensity is faintly visible from medial to lateral part of the lesion, with the area of low intensity staining roughly matching the ADC lesion (regions marked by dotted lines).

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