Gene expression-based comparison of the human secretory neuroepithelia of the brain choroid plexus and the ocular ciliary body: potential implications for glaucoma

Table 4 Gene expression profiles of candidate POAG disease genes in CPE and NPE

Candidate POAG disease genes	High gene expr.	Sign. diff. gene expr.
APOE	CPE
AKAP13	Both
ATOH7		NPE
C1QBP	Both
CDH1	CPE	CPE
CDKN2B		CPE
CHSY1	Both
COL8A2	Both
CYP1B1	Both	NPE
FBN1	Both	NPE
GSTM1	CPE
IBTK	Both
MFN2	Both
MYOC	NPE	NPE
OPTN	CPE
PAX6	NPE	NPE
RFTN1	NPE
SIX1		CPE
SIX6	NPE	NPE
TMCO1	Both
TMEM248	Both

High gene expr: Genes that are highly expressed in the CPE and/or NPE according to our gene expression microarray data of the CPE and NPE. Highly expressed gene are genes with mean expression values >90th percentile. Both = high expression in both CPE and NPE. Sign. diff. gene expr.: Genes that are statistically significant higher expressed in the CPE or NPE compared with the NPE and CPE, respectively, according to our gene expression microarray data. The selection criteria were fold change > 5 and p-value < 0.001.

ISSN: 2045-8118