Gene expression-based comparison of the human secretory neuroepithelia of the brain choroid plexus and the ocular ciliary body: potential implications for glaucoma

Janssen, Sarah F; Gorgels, Theo GMF; ten Brink, Jacoline B; Jansonius, Nomdo M; Bergen, Arthur AB

doi:10.1186/2045-8118-11-2

Fluids and Barriers of the CNS

Table 3 Genes coding for ion channels and transporters involved in CSF and AH production in the CPE and NPE

From: Gene expression-based comparison of the human secretory neuroepithelia of the brain choroid plexus and the ocular ciliary body: potential implications for glaucoma

Ion channels and transporters	Present in	Coding genes	High gene expr.	Sign. diff. gene expr.
Na⁺/K⁺ ATPase	CPE and CBE	ATP1A1	Both	NPE
		ATP1A2	Both
		ATP1A3	CPE
		ATP1A4
		ATP1B1	Both	CPE
		ATP1B2	Both
		ATP1B3	Both	NPE
Na⁺/2Cl^-/K⁺ co-transport	CPE and CBE	SLC12A1
Na⁺/2Cl^-/K⁺ co-transport	CPE and CBE	SLC12A2	CPE	CPE
Na⁺/Cl^- symport	CBE	SLC12A3
K⁺/Cl^- symport	CPE	SLC12A4
		SLC12A5
		SLC12A6
		SLC12A7	Both
		SLC12A9
Cl^-/HCO3^– exchanger	CPE and CBE	SLC4A1
		SLC4A2		CPE
		SLC4A3
Na⁺/HCO3^– symport	CPE	SLC4A4	NPE	NPE
		SLC4A5
		SLC4A7
		SLC4A8
		SLC4A9
		SLC4A10	CPE	CPE
Na⁺/H⁺ exchanger	CPE and CBE	SLC9A1
		SLC9A2
		SLC9A3
		SLC9A4
		SLC9A5
		SLC9A6
K⁺ channel	CPE and CBE	KCNA4		NPE
		KCNA5	CPE	CPE
		KCNAB1	NPE
		KCNB2		NPE
		KCNE1		CPE
		KCNF1		CPE
		KCNG1		NPE
		KCNH2		CPE
		KCNJ13	Both
		KCNK1	CPE	CPE
		KCNN2		CPE
		KCNN3		CPE
		KCNS1		NPE
Cl^- channel	CPE and CBE	CLCN1
		CLCN2
		CLCN3
		CLCN4
		CLCN5
		CLCN6
		CLCN7
Na⁺ channel	CPE and CBE	SCN1A
		SCN1B
		SCN2A		CPE
		SCN2B		NPE
		SCN3A
		SCN3B		NPE
		SCN4A
		SCN4B	NPE	NPE
		SCN5A
		SCN7A
		SCN8A
		SCN9A
		SCN10A
		SCN11A
Water channel	CPE and CBE	AQP1	Both
		AQP2
		AQP3
		AQP4		CPE
		AQP5
		AQP7
		AQP8
		AQP9
		AQP10
		AQP11

This table lists the ion channels and ion transporters involved in cerebrospinal fluid (CSF)/aqueous humor (AH) production, their presence in choroid plexus epithelium (CPE) and/or non-pigmented epithelium (NPE) of the ciliary body epithelium according to literature [20, 30] and the gene expression profiles in the CPE and NPE according to our microarray gene expression studies. Column 1: Ion channels and transporters involved in CSF/AH production. For the K⁺ channel, we only presented the highly and/or statistical significant different expressed genes of the CPE and NPE; Column 2 - Present in: The presence of the different ion channels and ion transporters are reviewed in [30] for the CPE and [20] for the NPE; Column 3 - Coding genes: the genes coding for the ion channels and ion transporters listed in column 1; Column 4 - High gene expr.: Here we indicate the genes that are highly expressed in the CPE and/or NPE according to our gene expression microarray data of the CPE and NPE. Highly expressed gene are genes with mean expression values >90th percentile. This means that these genes have an expression intensity that falls into the highest 10% intensity values of the microarray. Both = high expression in both CPE and NPE; Column 5 - Sign. diff. gene expr.: Here we indicate the genes that were statistically significant higher expressed in the CPE or NPE compared with the NPE and CPE, respectively, according to our gene expression microarray data of the CPE and NPE. The selection criteria were fold change > 5 and p-value < 0.001.

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ISSN: 2045-8118

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