Figure 2From: Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive ratsCerebrospinal fluid (CSF) system in a rat imaged with contrast-enhanced computed tomography (CT). Images show a 3D render reconstruction of CT images after 20 μL of radio-opaque contrast was injected into each lateral ventricle via cannulae guided through hollow screws inserted into the skull. Anatomical landmarks of the CSF system in the rat are based on a stereotaxic rat atlas [61]. Basal cisterns are not depicted in the rat atlas, but their location at the base of the brain is indicated by presence of contrast enhanced CSF in this location. An additional movie file shows this in more detail [see Additional file 2].Back to article page