Table 6 Unbound volume of distribution in the brain (V u,brain ) determined using Sprague–Dawley (SD) rat and Naval Medical Research Institute (NMRI) mouse brain slices
From: The brain slice method for studying drug distribution in the CNS
Ion class | Vu,brainml·g brain-1 | ||
|---|---|---|---|
SD rat | NMRI mouse | ||
Verapamil | Base | 46.6 (1.8) | 47.3 (4.4) |
Docetaxel | Base | 777 (217) | 796 (177) |
Oxycodone | Base | 4.20 (0.13)* | 3.75 (0.22) |
Digoxin | Base | 33.1 (6.0) | 44.9 (5.7) |
Gabapentin | Zwitterion | 4.49 (0.29) | 4.22 (0.93) |
Indomethacin | Acid | 14.1 (1.8) | 12.0 (1.8) |
Paroxetine | Base | 714 (72) | 596 (97) |
Thioridazine | Base | 2650 (232) | 1930 (170) |
Diazepam | Neutral | 17.8 (1.1) | 17.1 (2.3) |