Figure 12

Overview of the Giaever and Keese model [32]of the determination of specific parameters of cell-cell- and cell-substrate contact. Cells are modeled as circular disks hovering at a distance h above the electrode surface. The solid lines indicate paracellular current flow, the broken line represents transcellular current flow. R _b represents resistance of the cell-cell contact; C_m explains the capacity of the cell layers and the α term describes the impedance contributions arising from the proximity of the cell monolayer to the surface of the electrodes (cell-substrate contacts). |Ζ_model| describes the total impedance at different frequencies ω, the resistance of the cell-cell contact R_b, capacitance C_m of the cell layers and the α term. For more details on the equation see reference [32]. From [31] with permission.