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Table 2 Known BBB RMT receptors identified in HBEC-EMVs

From: Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells

Receptor BBB-Crossing Ligand References
Transferrin Receptor (TFRC) OX26 mAb [2]
Insulin Receptor (INSR) 83-14 mAb [37]
Low-Density Lipoprotein Receptor (LDLR) C7 mAb [38]
LDLR-related proteins (LRP1, LRP1B, LRP2) P97 proteins and Angiopep peptides [6, 39]
Cell cycle control protein 50A (TMEM30A/CDC50A) FC5 sdAb [3133]
Fc-Binding Proteins (e.g., FcγBP) Fc-containing antibodies