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Table 2 Known BBB RMT receptors identified in HBEC-EMVs

From: Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells

Receptor

BBB-Crossing Ligand

References

Transferrin Receptor (TFRC)

OX26 mAb

[2]

Insulin Receptor (INSR)

83-14 mAb

[37]

Low-Density Lipoprotein Receptor (LDLR)

C7 mAb

[38]

LDLR-related proteins (LRP1, LRP1B, LRP2)

P97 proteins and Angiopep peptides

[6, 39]

Cell cycle control protein 50A (TMEM30A/CDC50A)

FC5 sdAb

[3133]

Fc-Binding Proteins (e.g., FcγBP)

Fc-containing antibodies