Fingerprint changes in CSF composition associated with different aetiologies in human neonatal hydrocephalus: glial proteins associated with cell damage and loss

Table 1 Clinical variables of the normal and hydrocephalic neonates used in the study

Patient groups		Age (days)			Sex ratio (male: female)	Site of CSF collection	Source (UK: Pakistan)
Groups	n	Age range (days after birth)	Mean	SEM	Sex ratio (male: female)	Site of CSF collection	Source (UK: Pakistan)
Normal	8	8-92	24.50	9.72	5:3	Lumber	0:8
FOH	4	11-30	18.25	4.40	4:0	Lateral ventricle	1:3
LOH	4	60-300	153.75	55.58	3:1	Lateral ventricle	0:4
PHH	5	28-132	74.80	22.05	2:3	Lateral ventricle	5:0
SB/HC	4	5-105	41.00	22.79	2:2	Lateral ventricle	4:0

Number of patients, age (days post-partum), gender, and national distribution of the patients studied grouped by known aetiology. Late onset hydrocephalus (LOH) and spina bifida with hydrocephalus (SB/HC) infants are somewhat older than the other groups due to the nature of the condition and the time to receiving treatment. All CSF samples were collected from the lateral ventricle except normal samples that were collected by lumbar puncture. Although there is an age range in each group the low number of samples did not allow analysis of age-related changes. FOH: fetal-onset hydrocephalus, PHH: post-haemorrhagic hydrocephalus.

ISSN: 2045-8118