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Figure 1 | Fluids and Barriers of the CNS

Figure 1

From: Fibroblast growth factor 19 entry into brain

Figure 1

HPLC chromatogram of the degradation profiles of 125I-FGF19 in brain and serum 10 min after iv injection. The first fraction at the retention time of 5 min represents free 125I, the second fraction at retention time of 16 min represents small fragments of degraded 125I-FGF19, and the last fraction at retention time 28–30 shows intact 125I-FGF19. Most radioactivity in the serum coincided with that of the injection solution. The elution profile of brain supernatant in mice 10 min after iv injection of 125I-FGF19 was similar to that of ex-vivo processing (process control) where 125I-FGF19 was added in the homogenizer. The results indicate that 125I-FGF19 remained intact in the blood and brain compartments at this time (n = 3 /group).

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Fluids and Barriers of the CNS

ISSN: 2045-8118