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Table 2 Ventricular dilatation and outcome in hydrocephalic sheep with shunt treatment

From: Pre- and post-shunting observations in adult sheep with kaolin-induced hydrocephalus

Sheep #

Post kaolin day shunted

Post kaolin day of sacrifice

Ventricle enlargement Ratio V/C*

Comments

Controls

  

None

Non-treated normal animals

(0.030)

None

(0.028)

77R

7

16

Moderate

Found dead; shunt failure - choroid plexus ingrowth

(0.180)

78R

7

15

Moderate

Shunt failure - choroid plexus ingrowth / hemorrhage

(0.129)

194R

7

63

Moderate

Shunt failure - choroid plexus ingrowth

(0.113)

162R#

7

126

Mild

Shunt tip in choroid plexus / occlusion

(0.089)

102S

6

6

 

Problems with shunt insertion

113S

6

6

 

Intraoperative hemorrhage

118S

6

8

Mild

Meningitis and ventriculitis; catheter occluded by inflammatory cells

(ND)**

28S#

6

84

Mild

Shunt failure - choroid plexus ingrowth

(0.059)

75S

7

10

Mild

Asymmetric enlargement of ventricles, blood in CSF, ventriculitis, catheter occluded by inflammatory cells and blood

(0.053)

115S#

7

84

Moderate

Shunt failure - choroid plexus ingrowth

(0.152)

5S

7

11

Mild

Shunt failure - misplacement of catheter

(0.062)

104S

7

9

Moderate

Intraventricular / intraparenchymal hemorrhage; ventricular catheter unobstructed

(0.115)

129S

8

17

Mild

Shunt patent

(0.077)

0379

8

13

Mild

Ventriculitis, meningitis; shunt occluded by hemorrhagic material and bacterial debris

(0.074)

7023#

8

63

Mild

Shunt patent

(0.063)

47#

14

77

None 0.024)

Brain tissue growth into shunt

  1. # - animals that did well after shunting and were sacrificed at time rather than for clinical considerations. * V/C – ratio ventricle area/cerebrum area. **ND – not done.