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Table 2 Characteristics of different types of mass spectrometers

From: A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood–brain barrier in ddY, FVB, and C57BL/6J mice

Instrument Characteristics Performance for proteomics
Ion source Mass resolution Sensitivity Dynamic range Identification Quantification
QIT, LTQ ESI & MALDI Low to medium Medium Narrow to medium Medium Medium
QqQ ESI Low High Very wide Low Very high
TOF-TOF MALDI Medium Medium Narrow High Low
Q-TOF ESI & MALDI Medium Medium Medium High High
LTQ-Orbitrap ESI & MALDI Medium to high Medium Narrow to medium High Medium
FTICR ESI & MALDI Very high Medium Very narrow High Very low