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Table 2 Characteristics of different types of mass spectrometers

From: A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood–brain barrier in ddY, FVB, and C57BL/6J mice

Instrument

Characteristics

Performance for proteomics

Ion source

Mass resolution

Sensitivity

Dynamic range

Identification

Quantification

QIT, LTQ

ESI & MALDI

Low to medium

Medium

Narrow to medium

Medium

Medium

QqQ

ESI

Low

High

Very wide

Low

Very high

TOF-TOF

MALDI

Medium

Medium

Narrow

High

Low

Q-TOF

ESI & MALDI

Medium

Medium

Medium

High

High

LTQ-Orbitrap

ESI & MALDI

Medium to high

Medium

Narrow to medium

High

Medium

FTICR

ESI & MALDI

Very high

Medium

Very narrow

High

Very low