1. | Inter-organ difference in protein abundance. |
2. | Differences in functional protein localization in various organs and their impact on pharmacokinetics, efficacy, and drug toxicity. |
3. | Assay system of ADMET and efficacy based on differences in functional protein abundance in organs. |
4. | Characteristics of transgenic or gene-knockout animals based on the expression levels of a target protein and other non-target proteins. |
5. | Consistency between the characteristics of xenograft-transplanted animals and human diseases. |
6. | Inter-colony, inter-strain, inter-sex, inter-species, inter-racial, inter-disease, and intra-disease differences in the expression levels of functional proteins. |
7. | Impact of circadian rhythm and developing/aging on functional proteins. |
8. | Prediction of ADMET and efficacy of drugs in animals and humans, including the diseased state, based on the absolute levels of functional proteins. |
9. | Determinant factors that can affect inter-individual differences in ADMET, drug efficacy, and their impact on personalized medicine. |
10. | Suitable choice of molecular target-based drugs based on the absolute levels of target proteins in a drug-targeting organ. |