Identified protein | Gi access no. | Gene name | Function | Fold change | MW | pI |
---|---|---|---|---|---|---|
Proteins that are down-regulated-regulated in RLS/WED CSF | ||||||
Apolipo protein A-I (precursor) | 4557321 | APOA1 | Major protein component of high density lipoprotein (HDL) in plasma. Promotes cholesterol efflux from tissues to the liver for excretion. | −1.97 | 30758.93 | 5.56 |
Alpha-1-acid glycoprotein 1 | 112877 | AGP | Reduces neutrophil phagocytosis of bacteria, inhibits neutrophil migration and superoxide production, reduces activated platelet aggregation, and inhibits activated lymphocytes proliferation. | −5.25 | 23724.84 | 4.93 |
Proteins that are up-regulated in RLS/ WED CSF | ||||||
vitamin D-binding protein (precursor) | 181482 | GC | Binds vitamin D and its metabolites and transports them to target tissues | 2.32 | 54611.68 | 5.4 |
Prostaglandin D2 synthase 21kDa (brain) | 55962673 | PTGDS | Neuromodulator and trophic factor in the CNS. Involved in smooth muscle contraction and relaxation; and inhibits platelet aggregation. | 2.18 | 23049.57 | 9.92 |
cystatin C | 181387 | CST3 | Inhibitor of lysosomal proteinases and an extracellular inhibitor of cysteine proteases | 11.32 | 16047.18 | 9 |
β-Hemoglobin | 183830 | HBB | most common form of hemoglobin in adult humans | 4.53 | 16086.3 | 6.75 |