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Table 3 CSF proteins showing at least a two-fold difference in expression between RLS/WED and control subjects

From: Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease

Identified protein

Gi access no.

Gene name

Function

Fold change

MW

pI

Proteins that are down-regulated-regulated in RLS/WED CSF

Apolipo protein A-I (precursor)

4557321

APOA1

Major protein component of high density lipoprotein (HDL) in plasma. Promotes cholesterol efflux from tissues to the liver for excretion.

−1.97

30758.93

5.56

Alpha-1-acid glycoprotein 1

112877

AGP

Reduces neutrophil phagocytosis of bacteria, inhibits neutrophil migration and superoxide production, reduces activated platelet aggregation, and inhibits activated lymphocytes proliferation.

−5.25

23724.84

4.93

Proteins that are up-regulated in RLS/ WED CSF

vitamin D-binding protein (precursor)

181482

GC

Binds vitamin D and its metabolites and transports them to target tissues

2.32

54611.68

5.4

Prostaglandin D2 synthase 21kDa (brain)

55962673

PTGDS

Neuromodulator and trophic factor in the CNS. Involved in smooth muscle contraction and relaxation; and inhibits platelet aggregation.

2.18

23049.57

9.92

cystatin C

181387

CST3

Inhibitor of lysosomal proteinases and an extracellular inhibitor of cysteine proteases

11.32

16047.18

9

β-Hemoglobin

183830

HBB

most common form of hemoglobin in adult humans

4.53

16086.3

6.75