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Table 2 Values of rat and human physiological parameters

From: The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects

Physiological parameter Rat value Human value
Brain ECF volume 290 μl 240 ml
Total CSF volume 300 μl 140 ml
Brain ECF flow 0.2 μl/min 0.2 ml/min
CSF flow 2.2 μl/min 0.4 ml/min
Lateral ventricle volume 50 μl 25 ml
Cisterna magna volume 17 μl 7.5 ml
Subarachnoid space volume 180 μl 90 ml