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Table 2 Values of rat and human physiological parameters

From: The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects

Physiological parameter

Rat value

Human value

Brain ECF volume

290 μl

240 ml

Total CSF volume

300 μl

140 ml

Brain ECF flow

0.2 μl/min

0.2 ml/min

CSF flow

2.2 μl/min

0.4 ml/min

Lateral ventricle volume

50 μl

25 ml

Cisterna magna volume

17 μl

7.5 ml

Subarachnoid space volume

180 μl

90 ml