Figure 8

Observed and model prediction of remoxipride concentrations in human plasma (from [148,151,165] with permission). Human data on remoxipride and prolactin plasma concentrations were obtained following double intravenous administration of remoxipride at different time intervals. Data points on remoxipride concentrations in plasma (y-axis, concentration of remoxipride in μmol/L) as a function of time (x-axis, time in hours) are presented for each individual human subject (open symbols, DV). Using allometric scaling the preclinical PK model of remoxipride was tuned to the human PK model. The human PK model successfully predicted the remoxipride plasma kinetics in humans: the individual prediction of the median remoxipride concentrations is indicated (IPRE, ^________) as well as the population prediction (PRED, ---------).