Table 1 Role of cytokines in inflammation, angiogenesis and BBB permeability
From: Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies
Cytokines | Others name | Inflammation | Angiogenesis | BBB disruption | References |
|---|---|---|---|---|---|
CINC-1 | CXCL-1 or Gro-a | Pro | Pro | / | [34] |
[35] | |||||
CINC-2 | CXCL-3 or Gro-g | Pro | Pro | / | [35] |
[36] | |||||
CINC-3 | CXCL-2 or Gro-B | Pro | Pro | / | [35] |
[37] | |||||
CNTF | Â | Pro | / | / | [38] |
Fractaline | CX3CL-1 | Pro | Pro | / | [39] |
[40] | |||||
GM-CSF | Â | Pro | Pro | Pro | [40] |
[41] | |||||
[42] | |||||
S-ICAM-1 | CD54 | / | / | / | Â |
IFN-g | Â | Pro | Anti | Pro | [43] |
[41] | |||||
[44] | |||||
IL1-a | Â | Pro | Pro | Pro | [43] |
[45] | |||||
[46] | |||||
IL1-b | Â | Pro | Pro | Pro | [45] |
[47] | |||||
[48] | |||||
IL1-ra | Â | Anti | Anti | / | [49] |
IL-2 | Â | Pro | Pro | Pro | [50] |
[51] | |||||
IL3 | Â | Â | Pro | / | [52] |
IL4 | Â | Pro | Anti | Pro | [50] |
[51] | |||||
[35] | |||||
IL6 | Â | Pro and anti | Pro | Pro | [35] |
[48] | |||||
[53] | |||||
IL10 | Â | Anti | Anti | / | [54] |
IP-10 | CXCL10 | Pro | Anti | / | [35] |
LIX | CXCL5 | Pro | Pro | / | [35] |
L-selectine | CD62L | / | / | / | Â |
MIG | CXCL9 | Pro | Anti | / | [35] |
MIP-1a | CCL3 | Pro | / | / | [35] |
MIP-3a | CCL20 | Pro | / | / | [55] |
RANTES | CCL5 | Pro | Anti | Pro | [56] |
TIMP-1 | Â | / | Anti | / | [57] |
TNF-a | Â | Pro | Pro | Pro | [48] |
[35] | |||||
VEGF | Â | / | Pro | Pro | [58] |