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Table 1 Summary for arachnoid granulations perfused in vitro in the physiological (B to A direction) and non-physiological (A to B direction)

From: The function and structure of the cerebrospinal fluid outflow system

Direction of Perfusion

Pressure (mm Hg)

Flow Rate (μl/min)

Average cellular Lpμl/min per mmHg/cm2

Average A→B

3.33 ± 0.29

0.52 ± 0.29

0.28 ± 0.16

Average B→A

3.15 ± 0.08

4.3 ± 0.53

4.50 ± 0.53

p-value

0.35

7.40E-08

2.09E-07

  1. Data are average cellular hydraulic conductivity (Lp). Modified and reproduced with permission from Grzybowski et al [24].
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Fluids and Barriers of the CNS

ISSN: 2045-8118