Figure 1
From: Minocycline inhibits glial proliferation in the H-Tx rat model of congenital hydrocephalus
Astrocyte density (cells/μm3) in minocycline treated and untreated animals. The number of GFAP-immunoreactive cells was significantly higher (stars) in untreated hydrocephalic animals compared to both types of control (p < 0.001). Minocycline treatment significantly reduced the number of immunoreactive cells in hydrocephalic animals (p < 0.001). No significant differences were found between the control animals receiving minocycline and those that did not receive the drug, suggesting that minocycline has no effect on the normal brain. Data are mean ± SD, n = 5, cell counts were multiplied by 105 to get the actual cell number per μm3.