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Table 3 Number of shunt responders/non-responders depending on results of lumbar puncture or ICP monitoring

From: Cerebrospinal fluid pulse pressure amplitude during lumbar infusion in idiopathic normal pressure hydrocephalus can predict response to shunting

  Lumbar puncture ICP monitoring*
  CSFP wave amplitude
during opening phase
CSF wave amplitude
during lumbar infusion
ICP wave amplitude
  < 2 mmHg ≥ 2 mmHg < 4 mmHg ≥ 4 mmHg < 4 mmHg ≥ 4 mmHg
Responder (n = 35) 13 22 4 31 1 34
Non-Responder (n = 10) 8 2 6 4 7 3
Statistics Sensitivity = 63; Specificity = 80
PPV = 92; NPV = 38
Sensitivity = 88; Specificity = 60
PPV = 89; NPV = 60
Sensitivity = 97; Specificity = 70
PPV = 92; NPV = 88
  1. * Mean ICP wave amplitude from the period 11 p.m. to 7 a.m. PPV = Positive predictive value; NPV = Negative predictive value.