Figure 1
From: Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain
MRI imaging. A T2-weighted fast spin-echo sequence was used for quantification of lateral ventricular volume (A: control, B: 2W kaolin). Twenty-two contiguous T2-weighted axial slices were acquired in interleaved order, as shown in C. For quantification of water diffusion, four different regions of interest (cortex (yellow), periventricular (red), periaqueductal (purple) and CSF (green)) were drawn, using the b = 0 images, and apparent diffusion coefficient values were calculated for each ROI (D). In addition, T1-weighted pre (E) and post (F) contrast images were acquired. Blood brain barrier integrity was determined by subtraction of pre-contrast images from post-contrast images (G).