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Figure 1 | Cerebrospinal Fluid Research

Figure 1

From: CSF/serum quotient graphs for the evaluation of intrathecal C4synthesis

Figure 1

CSF/serum quotient diagram for C 4 (Reibergram). The upper hyperbolic curve (thick line) represents the discrimination line between brain-derived and blood-derived protein. Values above this upper line represent intrathecal C4 synthesis. The dashed hyperbolic lines indicate the extent of intrathecal synthesis as intrathecal fractions with 20, 40, 60, and 80% of the measured total immunoglobulin concentration in CSF, with reference to the discrimination line as 0% intrathecal synthesis. The limit of the reference range for QAlbumin between normal and increased CSF protein concentrations due to blood-CSF barrier dysfunction is indicated by the age-dependent vertical lines at Q Albumin 5.5 × 10-3 (up to 15 years), at QAlbumin 6.5 × 10-3 (up to 40 years), and at Q Albumin 8 × 10-3 (up to 60 years). Nine of the patients with neurological infectious meningoencephalitis (Black circle) had values above the upper solid line which indicate intrathecal synthesis of C4. Ten controls (Black triangle) without infectious neurological disorders had values in the normal range, indicating no intrathecal C4 synthesis. Also plotted are QIgA (White triangle) from 10 patients suffering from meningoencephalitis and five of these had IgA intrathecal synthesis. Two patients had no detectable IgA in CSF.

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