Figure 1

Representative coronal slices of T2-weighted MRI images comparing 21 day post-saline controls (A, C) to 21 day post-kaolin hydrocephalic brains (B, D). The hydrocephalic brains exhibited a dramatic increase in size of the lateral ventricles (LV), as well as the gross distortion of the caudate putamen (CP) and septum (S) following kaolin injections. The periventricular white matter (WM) appears to be thinned, stretched, and detached from the overlying cortical grey matter by either expansion of the lateral ventricle or edematous tissue. Additionally, image D demonstrates the cerebral aqueduct (CA) expanding caudally creating a possible communication to the subarachnoid space (SAS) that overlies the dorsal surface of the midbrain.