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Figure 5 | Cerebrospinal Fluid Research

Figure 5

From: Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure

Figure 5

IDE mRNA and protein expression following Pb exposure in rat CP tissue. Rats received ip injection of either Na acetate (control) or Pb acetate (27 mg Pb/kg) and tissues were analyzed 24 h after Pb exposure. A: IDE mRNA expression. No significant difference was observed between Pb-exposed and control groups as indicated by the ratio of IDE/GAPDH. B: Representative western blots of IDE protein expression in controls and Pb-treated rats. C: IDE expression estimated from the corresponding band densities in (B) and normalized to those of β-actin indicating. No significant difference was observed in IDE protein expression between Pb-treated and control rats. Data represent mean ± SD, n = 4. The data are representative of triplicate experiments.

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