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Figure 1 | Cerebrospinal Fluid Research

Figure 1

From: Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure

Figure 1

Confocal immunofluorescence images showing intracellular location of IDE in rat choroid plexus tissue following in vivo acute Pb exposure. A: The plexus tissues from a control rat. The IDE signals were present near the apical membrane of the epithelia, facing the CSF. B: Rats received a single ip injection of 27 mg Pb/kg. Twenty-four hours post exposure, there was no apparent sub-cellular re-localization of IDE following Pb exposure. C: Negative control without primary antibody. D, E, F: Transmission microscopy images. Note: The tissues in rats exposed to Pb (E) did not exhibit morphological alterations compared with controls (D). The images are representative of experiments run in triplicate.

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Fluids and Barriers of the CNS

ISSN: 2045-8118