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Figure 11 | Cerebrospinal Fluid Research

Figure 11

From: The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid

Figure 11

Proposed transport model for CSF nanostructures around the 3rd ventricle, with CSF neuroanatomical relations. A: Subarachnoid flow is directed from the pituitary fossa region, as indicated by arrows. The subarachnoid areas indicated for prostaglandin PGD and PGE receptors are quite discretely localized. CSF within the 3rd ventricle is separated by a small amount of tissue from the subarachnoid CSF areas, but these fluid compartments are only contiguous through the foraminal exits of Luschka and Magendie over considerable distance via the cisterna magna and back over the subarachnoid spaces. The boxed region in B is enlarged in C, which illustrates our proposal that nanospheres and nanoblobs (and the much less common nanodebris) arise directly from the brain/choroid/CSF surface, circulate, and contact a remote brain region or another nanostructure for signal transmission, probably regulated with specific receptor mechanisms.

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