Skip to main content

Table 3 Marker concentrations in lumbar CSF pre- and postoperatively.

From: Cerebrospinal fluid markers before and after shunting in patients with secondary and idiopathic normal pressure hydrocephalus

  

CSF preoperatively

CSF postoperatively

 

Lab reference value

Preop SNPH (n = 17)

Preop INPH (n = 18)

Preop Improved (n = 28)

Preop Unimproved (n = 7)

Postop SNPH (n = 17)

Postop INPH (n = 18)

Postop Improved (n = 28)

Postop Un-improved (n = 7)

Protein content:

         

Albumin (mg/L)

< 400

710 (511) pathol

544 (171) ns

650 (413)

529 (211) ns

1522 (3044) ↑ ***

1217 (1052) ↑ ***

1439 (2569) ↑ ***

1141 (935) ns

Albumin ratio

< 10.2

12.2 (11.0) pathol

8.4 (3.7) ns

10.8 (8.9)

8.0 (4.6) ns

24 (46) ↑ ***

21 (22) ↑ ***

24 (40) ↑ ***

19 (17) ns

Transmitter function:

         

HVA (nmol/L)

253 (109) [23]

209 (146) normal

225 (155) ns

240 (154)

140 (102) ns

229 (133) ns

218 (79) ns

230 (111) ns

202 (112) ns

5-HIAA (nmol/L)

125 (54) [23]

111 (56) normal

118 (95) ns

126 (80)

74 (53) ns

119 (50) ns

123 (33) ns

127 (42) ns

96 (38) ns

HMPG (nmol/L)

47 (10) [23]

37 (15) normal

36 (16) ns

39 (16)

28 (13) ns

38 (9) ns

44 (16) ns

43 (13) ns

31 (7) ns

NPY (pmol/L)

120–170 [25]

89 (26) low

106 (36) ns

95 (30)

108 (39) ns

110 (31) ↑ ***

155 (46) ↑ ***

124 (38) ↑ ***

161 (60) ns

VIP (pmol/L)

< 20 [14]

6.1 (1.7) normal

8.4 (4.9) ns

6.4 (1.4)

10.5 (7.9) ns

13 (5) ↑ ***

26 (22) ↑ **

16 (5) ↑ ***

36 (38) ns

GABA (nmol/L)

50–130 [36]

53 (30) normal

67 (44) ns

53 (25)

80 (58) ns

84 (64) ↑ **

103 (115) ns

91 (100) ↑ *

103 (25) ns

Demyelination:

         

Sulphatide (nmol/L)

< 300 [24]

210 (111) normal

208 (91) ns

210 (100)

204 (105) ns

239 (116) ns

360 (318) ns

279 (245) ns

363 (195) ns

Gliosis:

         

GD3 (nmol/L)

50 (12) [27]

39 (25) normal

38 (22) ns

35 (22)

50 (25) ns

56 (28) ↑ *

70 (33) ↑ ***

59 (32) ↑ **

79 (20) ns

Neuronal degeneration:

         

NFL (ng/L)

< 300 [28]

4884 (5855) pathol

1352 (2989) **

3637 (5338)

938 (1102) ns

3178 (4315) ns

1828 (3313) ns

2647 (3550)

2161 (1815) ns

TAU (ng/L)

< 400 [26]

311 (354) normal

229 (160) ns

267 (296)

275 (165) ns

341 (174) ns

651 (256) ↑ ***

449 (248)

633 (305) ns

  1. Values are given as mean (SD). Laboratory reference values are given in Column 1 where superscript numbers in square parentheses are literature references to laboratory reference values. INPH patients had significantly lower preoperative NFL than SNPH patients, as indicated in the preoperative INPH column, otherwise no differences were seen between groups preoperatively. There were no differences in preoperative CSF concentrations between improved and unimproved patients as indicated in the preoperative unimproved column. NFL was numerically, but not significantly, higher in the preoperative improved than in the unimproved group. There were no differences in postoperative CSF concentrations between improved and unimproved patients as indicated in the postoperative unimproved column. Postoperative values compared to preoperative levels are indicated in the postoperative columns. A number of markers showed significant increases postoperatively in the SNPH, INPH and improved groups as indicated by arrows. ns = non significant; * = p ≤ 0.05; ** = p ≤ 0.01; *** = p ≤ 0.001. The data for improved and unimproved patients has been published previously [18].
Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118