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Figure 1 | Cerebrospinal Fluid Research

Figure 1

From: Intrathecal synthesis of IgE in children with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis

Figure 1

CSF/serum quotient diagram for IgE (Reibergram) depicting the intrathecal synthesis of IgE in children with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis. The reference ranges for the normal CSF/serum ratios are depicted by the thicker upper hyperbolic line (Q lim) and the thinner lower hyperbolic line (Q low). Values above Q lim represent intrathecal IgE synthesis. The dashed lines indicate the extent of intrathecal synthesis as intrathecal fractions (IgE IF) as 20, 40, 60, and 80% of the measured total immunoglobulin concentration in CSF. The limit of the reference range for Q Albumin due to blood-CSF barrier dysfunction is indicated by three vertical lines for different ages: up to 15 years, up to 40 years, and up to 60 years. The diagram depicts the following ranges: 1, normal; 2, blood-CSF barrier dysfunction (i.e. reduced CSF turnover); 4, intrathecal immunoglobulin synthesis with no change in CSF turnover; 3, intrathecal immunoglobulin synthesis with reduced CSF turnover. Values below the lower hyperbolic line in range 5 would indicate a methodological fault. All the patients (filled circles) have intrathecal synthesis of IgE. The control samples (filled squares) were in the normal range indicating no IgE intrathecal synthesis.

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