Skip to main content
Figure 1 | Cerebrospinal Fluid Research

Figure 1

From: Hydrocephalus caused by conditional ablation of the Pten or beta-catenin gene

Figure 1

Mortality and hydrocephalus of Pten and beta-catenin conditional mutant mice. A, B: Kaplan-Meier survival curves of PtenloxP/loxP; Dmbx1-Cre, β-cateninloxP/loxP; Dmbx1-Cre and their littermate control mice. C, D: Overt appearance of pten and β-catenin mutant mice. Note that mutant mice manifest an enlarged head (white arrowheads). E-H: Dorsal view of the brains dissected from pten, β-catenin mutant and their littermate control mice. Cerebral cortex of the mutant mice was paper-thin due to the ventricular dilatation of hydrocephalus (white arrows). Dotted areas indicate superior and inferior colliculi. The β-catenin mutant mice lack these structures. E and F, postnatal day (P) 37; G and H, P 24. I, J: Coronal sections of β-catenin control and mutant brains at P 7. The β-catenin mutant brain has dilated lateral (v) and third ventricles and a thinner cortex. Scale bars, 1 mm. K-O: Coronal sections of the midbrain from β-catenin mutant and control mice at P 7. In the rostral sections of the β-catenin mutant brain, dilatation (asterisk) and abnormal protrusion (black arrowhead) in the midbrain aqueduct were observed. In the caudal sections, normal midbrain aqueduct was not detected in the mutant mice (black arrows). Scale bars, 500 μm.

Back to article page