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Table 4 CSF dynamics and volume in aging and neurodegeneration

From: Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

  Rat Aging* Human Disease
  3 mo 19 mo 30 mo Normal NPH AD
CSF Formation Rate (ml/min) 0.00121 0.00148 0.00065 0.40 0.25 0.20
CSF Volume (space) (ml) 0.156 0.196 0.308 150 300 250
CSF Turnover Rate (volumes/day) 11 10.8 3.0 4 1.2 1.2
  1. * CSF formation rate and volume in rats were determined by indicator dilution during ventriculo-cisternal perfusion [79]. CSF turnover rate = formation rate/volume.
  2. CSF formation rate and volume in patients were quantified by a modified Masserman technique [3]. NPH, normal pressure hydrocephalus; AD, Alzheimer's disease.
  3. Volumes/day = the number of times each day that the entire CSF volume is renewed.