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Table 4 CSF dynamics and volume in aging and neurodegeneration

From: Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

 

Rat Aging*

Human Disease†

 

3 mo

19 mo

30 mo

Normal

NPH

AD

CSF Formation Rate (ml/min)

0.00121

0.00148

0.00065

0.40

0.25

0.20

CSF Volume (space) (ml)

0.156

0.196

0.308

150

300

250

CSF Turnover Rate (volumes/day)

11

10.8

3.0

4

1.2

1.2

  1. * CSF formation rate and volume in rats were determined by indicator dilution during ventriculo-cisternal perfusion [79]. CSF turnover rate = formation rate/volume.
  2. † CSF formation rate and volume in patients were quantified by a modified Masserman technique [3]. NPH, normal pressure hydrocephalus; AD, Alzheimer's disease.
  3. Volumes/day = the number of times each day that the entire CSF volume is renewed.
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Fluids and Barriers of the CNS

ISSN: 2045-8118