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Table 1 Summary of polymer injection mortality and ventricular size index

From: Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats

Substance

Total Number Injected

Acute Mortality (a)

Time Points

Number with enlarged ventricles (b)

Ventricle Size Index (c)

Kaolin (30–35 μl)

40

4 (10%)

2d

4/4

 
   

5d

5/5

0.125 ± 0.024

   

10d

4/4

 
   

14d

21/23

0.168 ± 0.018

Matrigel (d)

42

7 (17%)

2d

2/3

 
  

p = 0.520

5d

1/4

0.103 ± 0.020

   

10d

1/1

 
   

14d

3/27

0.057 ± 0.021

    

p < 0.001

p < 0.05

Onyx-18 (e)

29

13 (45%)

2d

1/3

 
  

p < 0.001

5d

0/3

 
   

10d

0/2

 
   

14d

0/8

-

    

p < 0.001

 

Onyx-34 (f)

37

10 (27%)

2d

2/6

 
  

p = 0.076

5d

3/5

0.113 ± 0.013

   

10d

0/9

 
   

14d

2/7

0.135 ± 0.016

    

p < 0.001

 

NBCA (25–35 μl)

23

17 (74%)

5d

1/1

 
  

p < 0.001

14d

3/5

0.026 ± 0.016

    

p = 0.091

p < 0.05

Tisseel (g)

19

11 (58%)

14d

0/8

-

  

p < 0.001

 

p < 0.001

 

Collagen type1 (30–40 μl)

12

0 (0%)

14d

0/12

-

  

p = 0.562

 

p < 0.001

 
  1. a) Statistical comparison to kaolin using Fisher exact test (two-tailed)
  2. b) Enlarged ventricles defined as ventricle area index >0.02. Statistical comparison to kaolin using Fisher exact test (two-tailed) based upon total survivors studied at all time points
  3. c) Ventricle size index calculated on the MR slice immediately anterior the the third ventricle, total ventricle area/total brain area. The value shown is for successes only, mean ± SEM. Statistical comparison to kaolin based upon combined 10 day and 14 day data, ANOVA with Games-Howell post hoc intergroup analysis (which allows for different group sizes).
  4. d) 35 μl 0/11 successes; 75 μl 2/10 successful; 125 μl 4/11 successful; 150 μl 10/10 fatal
  5. e) 35 μl 7/7 fatal; 25 μl 1/7 successful; 15 μl 0/15 successful
  6. f) 35 μl 8/8 fatal; 25 μl 5/9 successful; 15 μl 2/20 successful
  7. g) 55 μl 9/9 fatal; 35 μl 2/10 fatal