Figure 8

AQP1 acts a non-selective cation ion conductance which can be activated by sodium nitroprusside (SNP) activates. Currents were recorded in: A (initial) unstimulated cells; B (SNP 1 mM) in the presence of 1 mM SNP (a nitric oxide donor which activates cGMP synthesis;); C (Cd²⁺ 200 μM) in 1 mM SNP plus 200 μM Cd²⁺ and D (Cd²⁺ 600 μM) in 1 mM SNP plus 600 μM Cd²⁺). In each experiment Vm was stepped for 200 ms from -110 to +40 mV at 10 mV increments. Figure reproduced with permission from Boassa et al [104].