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Figure 4 | Cerebrospinal Fluid Research

Figure 4

From: Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus

Figure 4

Scanning densitometry analysis of Western blots for GFAP in the parietal cortex. Above: Histogram of relative density. Overall, GFAP levels increased with age and with the progression of hydrocephalus, with significantly higher levels of GFAP being present in the 5d and 12d hydrocephalic animals. GFAP content also significantly increased over control in the 21d and 36d hydrocephalic animals. Shunting reduced GFAP levels from untreated hydrocephalic levels by 18% in the 21d shunted group (not significant). In the 36d group, there was a significant 23% decrease in the long term 36d shunted animals. Single asterisks indicates statistical significance at p < 0.05, double asterisk indicates significance at p < 0.01, brackets indicate comparison group. N = 5 for each group, values are means +/- standard deviation. Below: Immunoblot example showing clarity of bands, and standard in the left lane. The samples from the left are: lanes 3–7, 21 day control animal, 8–12, 21d shunted animals (shunted at 15d) and lanes 13–15, three of the 21d untreated hydrocephalic animals.

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