Table 2 The number and percentage of patients positive and negative for the CSF ADA test using the diagnostic cut-off value of > 11.39 U/L/min for the TBM patients, the non-TBM infectious meningitis patients and the control group with non-infectious neurological disorders. The sensitivity of the test for positive diagnosis was 82% and the specificity was 83%. The 95% confidence interval for sensitivity is between 73.91 and 90.19, while 95% confidence interval for specificity is between 77.67 and 88.99.
Patient groups | Number of patients with ADA activity >11.39 U/L/min | Number of patients with ADA activity < 11.39 U/L/min |
|---|---|---|
1. Tuberculous Meningitis (n = 117) | 96 (82%) | 21 (18%) |
Culture positive (n = 27) | 26 (96%) | 1 (4%) |
Clinically suspected (n = 90) | 70 (78%) | 20 (22%) |
2. Non-TBM infectious meningitis (n = 60) | 10 (17%) | 50 (83%) |
Pyogenic meningitis (n = 41) | 10 (24%) | 31 (76%) |
Viral meningitis (n = 19) | 0 (0%) | 19 (100%) |
3. Non-infectious neurological disorders (n = 104) | 0 | 104 (100%) |
Headache (n = 32) | 0 | 32 (100%) |
Stroke (n = 29) | 0 | 29 (100%) |
Venous sinus thrombosis (n = 13) | 0 | 13 (100%) |
Guillian-Barré syndrome (n = 12) | 0 | 12 (100%) |
Epilepsy (06) | 0 | 06 (100%) |
Other neurological disorders (n = 12) | 0 | 12 (100%) |