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Table 2 The number and percentage of patients positive and negative for the CSF ADA test using the diagnostic cut-off value of > 11.39 U/L/min for the TBM patients, the non-TBM infectious meningitis patients and the control group with non-infectious neurological disorders. The sensitivity of the test for positive diagnosis was 82% and the specificity was 83%. The 95% confidence interval for sensitivity is between 73.91 and 90.19, while 95% confidence interval for specificity is between 77.67 and 88.99.

From: Cerebrospinal fluid adenosine deaminase activity: A complimentary tool in the early diagnosis of tuberculous meningitis

Patient groups Number of patients with ADA activity >11.39 U/L/min Number of patients with ADA activity < 11.39 U/L/min
1. Tuberculous Meningitis (n = 117) 96 (82%) 21 (18%)
   Culture positive (n = 27) 26 (96%) 1 (4%)
   Clinically suspected (n = 90) 70 (78%) 20 (22%)
2. Non-TBM infectious meningitis (n = 60) 10 (17%) 50 (83%)
   Pyogenic meningitis (n = 41) 10 (24%) 31 (76%)
   Viral meningitis (n = 19) 0 (0%) 19 (100%)
3. Non-infectious neurological disorders (n = 104) 0 104 (100%)
   Headache (n = 32) 0 32 (100%)
   Stroke (n = 29) 0 29 (100%)
   Venous sinus thrombosis (n = 13) 0 13 (100%)
   Guillian-Barré syndrome (n = 12) 0 12 (100%)
   Epilepsy (06) 0 06 (100%)
   Other neurological disorders (n = 12) 0 12 (100%)