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Figure 1 | Cerebrospinal Fluid Research

Figure 1

From: Cerebrospinal fluid may mediate CNS ischemic injury

Figure 1

Effect of CSF removal and replacement of CSF with albumin- and gelatine-modified artificial CSF on rabbit spinal cord ischemia. Group 1 (closed circles). 1 h ischemia; prior treatment: none; ICP: 10–15 mmHg. Group 2 (open circles). 1 h ischemia; prior treatment: CSF depleted; ICP: 0 mmHg. Group 3 (closed triangles). 1 h ischemia; prior treatment: CSF replenished; ICP: 0 mmHg. Group 4 (open triangles). 1 h ischemia; prior treatment: 8% albumin in artificial CSF; ICP: 10–15 mmHg. Group 5 (closed squares). 1 h ischemia:; prior treatment: 1% gelatin in artificial CSF; ICP: 10–15 mmHg. Group 6 (open squares). 2 h ischemia; prior treatment: CSF depleted; ICP: 0 mmHg. Group 7 (closed diamonds). 3 h ischemia; prior treatment: CSF depleted; ICP: 0 mmHg. A. Neurological deficit (Tarlov score) determined at 7 d after spinal cord ischemia. Group 1 vs. groups 2, 4, 5 and 6; Group 3 vs group 2, 4 and 5; Group 7 vs. group 2 and 5 are significantly different when analyzed by Kruskal Wallis ANOVA followed by Dunn's test (p < 0.05). B. Histopathological score determined at 7 d after spinal cord ischemia by H&E staining. Groups 1, 3 and 7 vs. Groups 2, 4, 5 and 6 were significantly different analyzed by Kruskal Wallis ANOVA followed by Dunn's test (p < 0.05).

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