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Table 3 Stimulation of NaK2Cl cotransport by hormones, neurotransmitters and peptides that inhibit choroid plexus-CSF formation

From: Homeostatic capabilities of the choroid plexus epithelium in Alzheimer's disease

Active agent

Model

Species

Cotransport activity a

Reference

Atrial natriuretic peptide

Neuroblastoma

Human

82%

88

Angiotensin II

Aortic endothelium

Cow

38%

94

Arginine vasopressin

Medullary TALb

Mouse

66%

89

Serotonin agonistc

Fibroblasts

Cell line

49%

90

Adrenergic agoniste

Parotid gland epithelium

Rat

R5 stainingd

91

Adrenergic agoniste

Skeletal muscle (plantaris)

Rat

1700%

92

Basic fibroblast growth factor

Aortic endothelium

Cow

40%

93

  1. a Bumetanide-sensitive 86Rb uptake by cells
  2. b Thick ascending limb of kidney tubule
  3. c (-)-2,5-dimethoxy-4-bromoamphetamine
  4. d R5 antibody-detected phosphorylation of NKCC1 proportional to functional activity
  5. e Isoproterenol