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Table 3 Stimulation of NaK2Cl cotransport by hormones, neurotransmitters and peptides that inhibit choroid plexus-CSF formation

From: Homeostatic capabilities of the choroid plexus epithelium in Alzheimer's disease

Active agent Model Species Cotransport activity a Reference
Atrial natriuretic peptide Neuroblastoma Human 82% 88
Angiotensin II Aortic endothelium Cow 38% 94
Arginine vasopressin Medullary TALb Mouse 66% 89
Serotonin agonistc Fibroblasts Cell line 49% 90
Adrenergic agoniste Parotid gland epithelium Rat R5 stainingd 91
Adrenergic agoniste Skeletal muscle (plantaris) Rat 1700% 92
Basic fibroblast growth factor Aortic endothelium Cow 40% 93
  1. a Bumetanide-sensitive 86Rb uptake by cells
  2. b Thick ascending limb of kidney tubule
  3. c (-)-2,5-dimethoxy-4-bromoamphetamine
  4. d R5 antibody-detected phosphorylation of NKCC1 proportional to functional activity
  5. e Isoproterenol