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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Direct association with the vascular basement membrane is a frequent feature of myelinating oligodendrocytes in the neocortex

Fig. 4

Physiological analysis of vOLs reveals similar physiological properties as satellite oligodendrocytes.

(A) Schematic of a parasagittal acute slice and the recording location in the somatosensory cortex with a schematic of a vOL. (B) Example image of a vOL with patch-clamp pipette in oblique contrast and the corresponding GFP fluorescence image for identification. (C) Representative example traces from current-clamp whole-cell recordings of a vOL. (D) Example whole-cell voltage clamp recording of a vOL with corresponding command voltages. The steady-state measurement is indicated and displayed in E. (E) Current-voltage (I-V) relationship of vOLs compared to satellite OLs shows a linear I-V relationship for oligodendrocytes from both anatomical locations in the steady-state. (F) Principal component analysis based on the electrophysiological parameters shows no separation of the two groups of oligodendrocytes.

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Fluids and Barriers of the CNS

ISSN: 2045-8118