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Table 2 Mean f values (%) of IVIM MRI in 45 regions of interests among three age group in healthy controls and patients with iNPH

From: Usefulness of intravoxel incoherent motion MRI for visualizing slow cerebrospinal fluid motion

Region of interest

Healthy volunteer

iNPH patient

(36)

P-valuea

P-valueb

 < 40 years

(47)

40–59 years

(49)

60 <  = years

(36)

Lt. lateral ventricle (anterior horn)

43.2 ± 18.6

44.0 ± 12.4

48.9 ± 19.1

23.9 ± 7.8

 < 0.001

0.274

Rt. lateral ventricle (anterior horn)

43.0 ± 17.4

46.9 ± 12.0

53.8 ± 16.7

24.5 ± 8.0

 < 0.001

0.017

Lt. lateral ventricle

(body)

35.4 ± 14.8

33.8 ± 13.7

29.4 ± 16.5

19.9 ± 6.3

 < 0.001

0.028

Rt. lateral ventricle

(body)

39.2 ± 15.3

32.0 ± 11.7

27.3 ± 15.7

21.7 ± 6.2

0.108

 < 0.001

Lt. lateral ventricle

(trigon)

52.8 ± 15.0

53.4 ± 12.6

58.8 ± 12.2

29.4 ± 13.4

 < 0.001

0.164

Rt. lateral ventricle (trigon)

53.6 ± 15.0

52.9 ± 10.0

58.6 ± 14.0

31.1 ± 11.3

 < 0.001

0.112

Lt. lateral ventricle (inferior horn)

58.0 ± 13.1

56.3 ± 12.5

64.2 ± 11.5

36.9 ± 12.1

 < 0.001

0.014

Rt. lateral ventricle (inferior horn)

58.1 ± 11.8

56.8 ± 11.1

66.4 ± 7.6

39.0 ± 12.2

 < 0.001

 < 0.001

Lt. foramen of Monro

75.1 ± 13.2

78.0 ± 10.4

79.6 ± 7.9

69.2 ± 16.9

0.005

0.419

Rt. foramen of Monro

72.0 ± 13.3

76.0 ± 10.1

78.1 ± 10.8

67.6 ± 18.2

0.008

0.041

3rd ventricle

(anterior part)

81.2 ± 9.8

81.5 ± 11.2

76.1 ± 20.1

48.2 ± 25.6

 < 0.001

0.755

3rd ventricle

(posterior part)

82.5 ± 6.9

83.7 ± 6.8

84.6 ± 6.2

80.3 ± 8.1

0.026

0.235

Cerebral aqueduct

69.1 ± 11.1

68.0 ± 13.5

74.4 ± 9.0

74.6 ± 8.7

0.955

0.026

4th ventricle (upper part)

75.1 ± 7.2

73.1 ± 8.3

78.0 ± 5.8

75.7 ± 8.2

0.277

0.015

4th ventricle (middle part)

50.2 ± 15.9

49.7 ± 16.1

58.9 ± 17.6

54.2 ± 18.5

0.224

0.027

4th ventricle (lower part)

61.6 ± 12.1

61.3 ± 15.5

62.3 ± 14.5

67.1 ± 13.3

0.096

0.871

Lt. foramen of Luschka

49.3 ± 12.3

48.2 ± 10.5

57.8 ± 14.4

66.6 ± 14.1

0.004

0.001

Rt. foramen of Luschka

46.3 ± 8.9

46.1 ± 10.6

58.5 ± 12.6

69.0 ± 10.0

 < 0.001

 < 0.001

Foramen of Magendie

74.6 ± 8.4

75.3 ± 9.6

78.3 ± 7.4

78.0 ± 7.5

0.698

0.116

Foramen magnum

75.7 ± 12.3

69.0 ± 14.4

77.7 ± 11.8

62.7 ± 20.7

 < 0.001

0.008

Lt. cerebellopontine angle

84.1 ± 8.2

85.5 ± 6.4

85.9 ± 6.9

80.3 ± 10.8

0.023

0.523

Rt. cerebellopontine angle

83.8 ± 8.2

86.5 ± 7.0

88.0 ± 5.6

79.2 ± 11.8

 < 0.001

0.022

Prepontine cistern

88.5 ± 3.9

87.6 ± 3.5

88.4 ± 3.2

87.1 ± 6.1

0.719

0.359

Suprasellar cistern

89.7 ± 4.7

90.2 ± 2.6

89.9 ± 3.7

83.9 ± 12.6

0.006

0.952

Interhemispheric fissure (lower part)

80.9 ± 8.1

82.8 ± 7.0

85.3 ± 6.3

78.9 ± 13.1

0.011

0.033

Quadrigeminal cistern

68.0 ± 11.9

73.0 ± 9.4

71.4 ± 15.5

60.2 ± 16.4

0.001

0.081

Lt. ambient cistern

82.4 ± 9.5

84.9 ± 4.2

86.8 ± 5.4

71.5 ± 15.3

 < 0.001

0.013

Rt. ambient cistern

83.2 ± 8.7

84.5 ± 5.6

88.6 ± 3.9

73.0 ± 15.0

 < 0.001

 < 0.001

Lt. carotid cistern

89.3 ± 4.2

89.3 ± 4.8

91.9 ± 1.9

86.1 ± 7.7

 < 0.001

 < 0.001

Rt. carotid cistern

89.9 ± 4.4

89.7 ± 3.5

91.3 ± 2.0

86.7 ± 6.2

 < 0.001

0.097

Lt. Sylvian fossa

75.1 ± 16.6

80.9 ± 12.1

89.4 ± 4.6

62.6 ± 22.8

 < 0.001

 < 0.001

Rt. Sylvian fossa

72.8 ± 17.4

80.2 ± 11.0

89.1 ± 5.4

63.2 ± 22.2

 < 0.001

 < 0.001

Lt. Sylvian sulcus

(anterior ramus)

56.0 ± 14.8

60.7 ± 12.0

69.9 ± 10.6

49.4 ± 18.9

 < 0.001

 < 0.001

Rt. Sylvian sulcus

(anterior ramus)

56.3 ± 14.7

65.3 ± 10.7

69.6 ± 9.1

51.6 ± 18.7

 < 0.001

 < 0.001

Lt. Sylvian sulcus (posterior ramus)

69.0 ± 14.2

73.9 ± 9.6

81.3 ± 5.6

56.8 ± 20.1

 < 0.001

 < 0.001

Rt. Sylvian sulcus (posterior ramus)

69.1 ± 12.9

75.2 ± 9.9

80.8 ± 6.4

57.1 ± 18.4

 < 0.001

 < 0.001

Lt. central sulcus

52.4 ± 13.4

54.6 ± 10.0

58.8 ± 11.0

36.9 ± 10.4

 < 0.001

0.035

Rt. central sulcus

53.7 ± 12.6

53.8 ± 9.5

56.9 ± 14.0

39.9 ± 10.9

 < 0.001

0.347

Lt. superior frontal sulcus

45.6 ± 13.7

49.5 ± 10.7

55.2 ± 14.1

36.6 ± 12.3

 < 0.001

0.008

Rt. superior frontal sulcus

46.1 ± 15.2

51.4 ± 10.8

57.3 ± 12.0

36.6 ± 11.1

 < 0.001

 < 0.001

Lt. marginal sulcus

55.8 ± 12.0

59.9 ± 11.5

59.0 ± 13.5

38.7 ± 12.4

 < 0.001

0.140

Rt. marginal sulcus

56.3 ± 12.4

59.4 ± 11.1

57.0 ± 14.9

36.2 ± 12.4

 < 0.001

0.413

Interhemispheric fissure (upper part)

41.5 ± 17.0

48.1 ± 16.6

54.0 ± 16.7

35.2 ± 16.9

 < 0.001

0.011

Lamina terminals cistern

47.6 ± 18.5

39.2 ± 16.2

37.7 ± 18.3

29.3 ± 10.4

0.033

0.041

Interpeduncular cistern

39.0 ± 11.4

34.5 ± 12.6

35.0 ± 15.3

30.9 ± 13.3

0.290

0.066

  1. aP-value: probability value for the Mann–Whitney-Wilcoxon test between iNPH patients and healthy volunteer aged ≥ 60 years
  2. bP-value: probability value for the Kruskal–Wallis test among 3 age groups of healthy volunteer