Variables | Baseline | Post-operative | df | p valuea |
---|---|---|---|---|
A. Shunt responders (SR, n = 20) | ||||
TUG, mean (SD) | ||||
Time to complete (s) | 14.7 (4.1) | 11.2 (4.3) | 19 | <0.001 |
Number of steps | 21.9 (7.0) | 18.1 (7.2) | 19 | 0.001 |
iNPHGS, median (range) | ||||
Gait disturbance | 2.0 (2–3) | 1.0 (0–3) | <0.001 | |
Cognitive disturbance | 3.0 (0–3) | 2.0 (0–3) | 0.001 | |
Urinary disturbance | 1.5 (0–3) | 0.0 (0–2) | 0.004 | |
Total | 6.5 (2–9) | 3.0 (1–7) | <0.001 | |
MMSE, mean (SD) | 21.5 (4.6) | 24.0 (4.3) | 19 | 0.008 |
FAB, mean (SD) | 10.7 (2.3) | 12.9 (3.1) | 19 | 0.002 |
Left VV/ICV ratio (%), mean (SD) | 8.29 (1.99) | 6.59 (2.03) | 19 | <0.001 |
Left hemispheric FA, mean (SD) | 0.386 (0.022) | 0.382 (0.026) | 19 | NS |
Left hemispheric MD (×10−3 mm2/s), mean (SD) | 0.813 (0.036) | 0.816 (0.035) | 19 | NS |
Mean FA of the left corona radiata, mean (SD) | 0.624 (0.041) | 0.592 (0.048) | 19 | <0.001 |
B. Shunt non-responders (SNR, n = 8) | ||||
TUG, mean (SD) | ||||
Time to complete (s) | 15.6 (3.1) | 14.2 (3.5) | 7 | NS |
Number of steps | 22.6 (4.0) | 20.5 (5.0) | 7 | NS |
iNPHGS, median (range) | ||||
Gait disturbance | 2.0 (1–4) | 2.0 (1–4) | NS | |
Cognitive disturbance | 2.5 (1–3) | 2.0 (1–3) | NS | |
Urinary disturbance | 2.0 (0–4) | 2.0 (0–4) | NS | |
Total | 7.0 (4–9) | 7.0 (4–9) | NS | |
MMSE, mean (SD) | 22.3 (5.0) | 22.3 (5.0) | 7 | NS |
FAB, mean (SD) | 11.0 (3.8) | 11.0 (3.7) | 7 | NS |
Left VV/ICV ratio (%), mean (SD) | 7.19 (1.99) | 6.40 (1.79) | 7 | 0.005 |
Left Hemispheric FA, mean (SD) | 0.380 (0.024) | 0.375 (0.030) | 7 | NS |
Left Hemispheric MD (×10−3 mm2/s), mean (SD) | 0.829 (0.068) | 0.876 (0.099) | 7 | NS |
Mean FA of the left corona radiata, mean (SD) | 0.612 (0.043) | 0.607 (0.044) | 7 | NS |