A comparison between the pathophysiology of multiple sclerosis and normal pressure hydrocephalus: is pulse wave encephalopathy a component of MS?

Table 3 AVD and pulsation stroke volume

	AVD (ms)	Arterial SV (µL)	SSS SV (µL)	ST SV (µL)	%SSS SV	%ST SV
Normal young n = 20
Mean	112	914	273	73	31	8.7
SD	67	264	96	30	9	3.9
Normal elderly n = 12
Mean	111	1331	308	71	23	5.6
SD	50	374	124	20	7	1.8
p value NY vs NE	NS	0.0006*	NS	NS	0.02*	0.02*
Multiple sclerosis n = 20
Mean	73	1152	188	50	16	4.4
SD	39	350	44	30	9	3.0
p value MS vs NY	0.02*	0.02*	0.007*	0.02*	0.0001*	0.0003*
Hydrocephalus n = 20
Mean	47	963	170	42	19	4.4
SD	24	375	91	26	8	2.3
p value NPH vs NE	0.0002*	0.02*	0.0005*	0.002*	NS	NS

AVD arteriovenous delay; ms milliseconds; SV stroke volume; SSS superior sagittal sinus; ST straight sinus; SD standard deviation; *t test p value <0.05; MS multiple sclerosis; NPH normal pressure hydrocephalus; NS not significant; NY normal young; NE normal elderly; p values are adjusted for age

ISSN: 2045-8118