Volume 12 Supplement 1
Endoscopic third ventriculostomy (ETV) for treatment of adult hydrocephalus: long-term followup with 163 patients
© Isaacs et al. 2015
Published: 18 September 2015
Treatment of specific patterns of symptomatic hydrocephalus in the adult patient may be accomplished with endoscopic third ventriculostomy (ETV) as an alternative to insertion of a ventriculoperitoneal (VP) shunt or when VP shunt failure occurs. Treatment of hydrocephalus with a VP shunt, while effective, is associated with a significant shunt failure rate that results in VP shunt revision surgery. This review examines a single center experience with ETV to treat hydrocephalus in symptomatic adult patients.
Adult patients (>/=18 years) with a diagnosis of hydrocephalus who were treated with ETV in Calgary between January 1994 and July 2014 were reviewed using a clinic database and registry. All patients were treated by one neurosurgeon.
163 adult patients with symptomatic hydrocephalus treated with ETV were identified (male=92; female=71). Mean age at the time of ETV was 46 years (range 18-83 years). 112 underwent ETV as a primary treatment and 51 patients underwent treatment after presenting with VP shunt failure (secondary ETV). 113/163 patients had a diagnosis of aqueductal stenosis, 22/163 had a diagnosis of tumor. Mean followup was 8.2 years (range 0.3-18.4 years). Symptoms in 149/163 (91.4%) of ETV patients were better or unchanged at last followup. 104/118 (88.1%) of primary ETV patients were shunt free at last followup. 39/45 (86.7%) of secondary ETV patients were shunt free at last followup.
Endoscopic (ETV) treatment of hydrocephalus is an effective longterm treatment in a select population adult patients with hydrocephalus. Outcome/results are similar for patients where ETV is used as either a primary or secondary treatment. 87-88% of patients remain shunt free with a mean 8.2 years of followup.
To understand the role of ETV for primary treatment of hydrocephalus in the adult patient.
To understand the role of ETV for secondary treatment of hydrocephalus in the adult patient.
- Isaacs A M, Yuh S J, Hurlbert R J, Mitha A: Penetrating intracranial nail-gun injury to the middle cerebral artery: A successful primary repair. Surgical Neurology International. 2015, sni_178_1. SubmittedGoogle Scholar
- Honey C R, Yeomans W, Jayaraman J, Isaacs A, Honey C M: The Dying Art of Percutaneous Cordotomy in Canada. Journal of Palliative Medicine. 2014, 17 (5): PMID: 24717005Google Scholar
- Paterson R Z, Parno T J, Isaacs A M, Abizaid A: Interruption of Ghrelin Signaling in the PVN Increases High-Fat Diet Intake and Body Weight in Stressed & Non-Stressed C57BL6J Male Mice. Frontiers in Neuroscience. 2013, 7 (167): PMID: 24062637Google Scholar
- King S J, Isaacs A M, O'Farell E, Abizaid A: Motivation to Obtain Preferred Foods is Enhanced by Ghrelin in the Ventral Tegmental Area. Hormones and Behavior. 2011, 60: 572-580. 10.1016/j.yhbeh.2011.08.006. PMID: 21872601View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.