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Figure 1 | Cerebrospinal Fluid Research

Figure 1

From: Expression of junctional proteins in choroid plexus epithelial cell lines: a comparative study

Figure 1

Schematic representation of AJ and TJ complexes in choroidal epithelial cells. AJs are formed by E-cadherin, a single pass transmembrane protein that exhibits Ca2+-dependent homophilic interactions. The intracellular domain of E-cadherin binds to β-catenin, which binds to α-catenin, which in turn interacts with actin, and this catenin-mediated anchorage of E-cadherin to the actin cytoskeleton is required for strong cell-cell adhesion. Occludin and the members of the family of claudin proteins are the major constituents of TJs. Occludin and claudins are connected to the actin filaments through cytoplasmic adaptor protein, ZO-1.

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Fluids and Barriers of the CNS

ISSN: 2045-8118