Elevated cerebrospinal fluid pressure in patients with Alzheimer's disease

Table 1 Baseline characteristics of the seven AD-NPH subjects. The imaging studies were read by an independent neuroradiologist. The normal MDRS score is 142–144, the normal MMSE score is 27–30. Consequently, these patients are in the mild to moderate range of AD.

Subject number	1	2	3	4	5	6	7
Age	68	66	63	71	73	56	70
Gender	Male	Female	Female	Male	Male	Female	Male
Highest Education	<8^th Grade	8^th – 12^th Grade	>12^th Grade	>12^th Grade	8^th -12^th Grade	8^th – 12^th Grade	8^th – 12^th Grade
Neurological History (other than AD)	None	None	None	None	None	Restless legs	Insomnia, headaches
Genitourinary History	Urinary Tract Infection, prostatitis	None	None	None	None	None	Overactive bladder, prostate hypertrophy
Abnormal Posture	Absent	Absent	Absent	Absent	Absent	Absent	Absent
Brain Image Type	MRI	MRI	MRI	CT	MRI	MRI	CT
Markedly Enlarged Ventricles?	No	No	No	No	No	No	No
Other Lesions on Brain Scan	None	Non-specific deep white matter changes	Small amt periventricular white matter changes	None	Mild changes noted on Flair image	None	None
Gait	Normal	Normal	Normal	Normal	Normal	Normal	Poor balance, unable to tandem gait, slow gait, no arm swinging
MDRS	111	123	127	120	120	118	109
MMSE	19	25	26	25	21	20	26
Opening pressure	240	235	260	260	250	220	280

ISSN: 2045-8118